Myopia-preventing high intensity illumination apparatus for illuminating eyeballs and surrounding tissues via light that penetrating periorbital skin, subcutaneous tissue, then pass through cornea, iris, uvea, sclera and choroid

ABSTRACT

The present invention provides a myopia-preventing high intensity illumination apparatus for illuminating eyeballs and surrounding tissues via light that penetrating periorbital skin, subcutaneous tissue, then pass through cornea, iris, uvea, sclera and choroid, comprising a light source and a controller electrically connects to the light source, wherein the light source is projects to and illuminates on skin surrounding eyes, penetrates and enters subcutaneous tissue, iris, ciliary body and lens, as well as penetrates peripheral tissues of eyeballs, sclera, uvea, choroid and retinal pigment epithelium, and indirectly enters into vitreous and retina, so as to prevent myopia from further worsening by inducing microscopic biochemical reactions.

This application is a Continuation-in-part application of U.S. patent application Ser. No. 17/014,201, filed on Sep. 8, 2020.

BACKGROUND OF THE INVENTION a) Field of the Invention

The present invention relates to a myopia-preventing high intensity illumination apparatus for illuminating eyeballs and surrounding tissues via light that penetrating periorbital skin, subcutaneous tissue, then pass through cornea, iris, uvea, sclera and choroid, specifically a device and method of transcutaneous, trans uveous, transscleral, trans choroid, through an extra-pupillary pathway to apply high intensity illumination to eyes and periorbital region.

b) Background

Many studies found that high intensity light illumination for eyeball has great effects on public health, studies (1-9) found that children stay enough outdoor time can prevent myopia progression, animal study found that ambient light by LED illumination of 40000 lux can stop the chicken myopia progression, while another study of Oyama et al., (2019, Cell Reports 28, 1471-1484) (10) found that ambient light by 10000 lux can protect animal from heart injury, besides, they illuminated light of same intensity on healthy human for half hour a day for one week, they found the aggregate(triglycerate) of glaucose metabolism lowered, then the authors suggest that heart diseased human to receive high intensity light therapy for one week before heart surgery in order to increase the heart muscle protection, but the study admitted that they cannot standardized the pathway and angle of the main light incident to the eyeball.

So many studies suggest that high intensity light illumination is important in prevention of myopia, heart disease and DM. But most of all did not understand that due to the convergence effect of lens in eyeball, most incoming light through pupil will convergent and focus on fovea of macula, hence in practical study we found that human cannot stand for staring at light which is pass directly through pupil of intensity more than 1500-2000 lux for long time. So, in study of Oyama et al., the experiment animal is mouse which is reared in a box of limited space, Since mouse is a nocturnal animal, it will avoid high intensity light and turn their head and find an angle to low down the light illuminated into their eyeball, many light will fall on their eyelids, only light that partially blocked by eyelids, the reared mouses can stand the light of intensity of 10000 lux shine on their eye region, this is also true when they studied on light of 10000 lux illuminated on healthy human, they found and admitted that their illumination method and light angle is not standardized.

The outdoor sunlight can easily reach the intensity of 40000-120000 lux and excess to 200000 lux, in review of photograph taking from sunny seashore we found most people turn their head away from gazing sun, turn their head to the shadow side, or look downward or sideward, to avoid the sun from direct shine into their pupil, if in need of looking at sunny side, they will partially close the eyelids and turn a little downward to prevent sunlight from directly shine into the pupil. This is also true for animal raised in high ambient light, it will avoid ambient light from directly shine through their pupil, especially for nocturnal animal like mouse. Light of intensity greater than 2000 lux will shine on skin of eyelids and pass-through skin or through extra-pupillary pathway to illuminate eyeball.

The light pass through extra-pupillary or transcutaneous pathway will penetrate the skin or cornea then pass through iris, peripheral lens, into vitreous, then on peripheral retina, or pass backwardly through conjunctiva then pass through sclera, then pass through, ciliary body or uvea tract or choroid then pass through retinal pigment epithelium, then backwardly into peripheral retina, the majority of light not convergent by lens to focus on macula, while it fall mostly on the peripheral retina, which is the main area of myopia control found by many studies.

Most people thought that light therapy to eyeball need to shine the light directly on front of eyeball, but the light enter the front face of eyeball will convergent by lens and focus on macula, the intensity of light will be greatly increased, hence the front incoming light will be limited by light intensity of 1500-2000 lux, or it will burn and injure the macula of retina.

Studding the structure of eyeball, light shine directly on front of pupil include visual field of 90 degree wide, the light pass-through pupil will convergent and focus by lens of eyeball on a small area of macula, which is only 5 mm diameter. Due to the convergence and concentration effect of lens, the light intensity of incident light will be limited to 2000 lux, and the light fall only on a small area of retina(macula), While the other area of retina construct majority of the retina plays many important roles on physiology effect role of human. Such as myopia control, heart muscle protection, metabolism stabilization, circadian rhythm control. The light of intensity more than 2000 lux will shine on eyeball only by extra-pupillary or transcutaneous pathway, or it will burn and injure the macula of retina. While the high intensity light pass through extra-pupillary or transcutaneous pathway to shine on eyeball play an important role on control of human health.

In view of this, we found that high intensity light in outdoor activity, it affects eyeball through extra pupillary pathway, and through transcutaneous rout in a diffuse and relatively backward shine on eyeball. Only light intensity lower than 2000 lux will pass through pupillary pathway. It is important for image detect, and focus and convergent on small area of retina, macula. The high intensity light of more than 2000 lux shine eyeball by extra-pupillary pathway, it pass through skin, or iris, ciliary body, uvea tract, sclera, choroid, retinal pigment epithelium, then indirectly or backwardly into retina, especially most retina. The peripheral retina construct most of the eyeball retina, it is the major area of retina which controls the heath of human.

Modern people live in a style of lacking high intensity light illumination, In Asia, school children lack of outdoor activity due to competition in study work, many studies found that increase outdoor activity time will lowdown the myopia progression. While the outdoor time need to influence the myopia progression is 2-3 hour outdoor a day, most student cannot afford it. Hence the myopia rate in asia is top of the world, and due to modern lifestyle of high near work, high cell phone time, high indoor TV time, WHO estimated the world myopia rate of 2050 will approach 50%. This is a great healthy issue.

Heart disease and Diabetis meliasis is also increased in recent years. Many studies found that high light outdoor illumination has positive effect on decrease the rate of those diseases.

Even healthy people in normal work is lacking enough outdoor illumination, they live in modern house with standard light intensity of 500 lux. Get up early in morning, then drive car to office, and work in artificial lighting workspace of 500 lux illumination, then when complete day time work, they drive back home, still live into home of 500 lux illumination. The intensity of normal outdoor day light is 40000-200000 lux, far above the lighting standard of 500 lux in classroom and modern workspace and living house. The lack of enough outdoor time and enough high outdoor light illumination is a public health problem of modern human.

Beside school children and indoor worker, many diseased people admitted to hospital bed ward, cannot afford outdoor activity, they lack high intensity light illumination, their heart and glucose metabolism will be greatly hampered. They are also in need of high intensity illumination to improve their health.

So, it is our purpose to invent an effective and high efficient devise to provide high intensity light illumination of eyeball and periorbital region to help people who do not have enough outdoor time.

Study of outdoor activity we found that due to avoidance of direct shine by sunlight, people will wear hat, take umbrella, walk into shadow of tree or shelter, or in case of no shelter to avoid direct sun shine, they will turn backward or sideward or downward of their head, or closing their eyelids or wear sunglasses, we found that only about one twentieth of outdoor time that the sun light shine directly on eye region.

So if we can provide an illumination apparatus with safe and high intensity and high efficient full spectrum light to shine on eye region, only 10 to 15 minutes will equivalent to 3 to 5 hours of sun effect in outdoor activity, it will greatly help for health of those who cannot afford receiving enough outdoor time.

So, it is the goal of our invention to provide a method and device for high intensity and highly efficient illumination of eyeball and periorbital region, which the illumination intensity can approach 40000 lux to 200000 lux.

c) Description of the Prior Art

Myopia is a worldwide problem, especially in Asia. Myopia tends to develop in childhood and progress in severity until adulthood. Myopia associates with many disadvantages such as inconvenient in work, cost for glasses or contact lenses as well as increasing eye diseases relate to myopia. Hence, the prevention of progression of myopia is a great health issue.

PRIOR ARTS

One invention CN101858573A is a high illuminance classroom lamp, refer to apply high illuminance classroom lamp to help the students in preventing myopia. Another invention EP3141282A1 is a device for treating, preventing, or reducing myopia, or the risk thereof, use a display in front of student to apply various lights (illuminance of 0.6 to 1000 lux) to stimulate eyes. Another invention US20170072218A is a Method and apparatus for reducing or preventing myopia, apply a display to stimulate the temporal region of the eye to prevent myopia. Another invention EP2155041A1 is a determination of optical adjustments for retarding myopia progression, provides an anti-myopia lens to retard myopia progression. Another invention U.S. Pat. No. 9,709,826B2 is an ocular lens, apply ocular lens with filtered bands of wavelength to prevent myopia progression. Another invention WO2015152818A1 is a device to prevent a condition or disease associated with lack of outdoor time, apply a wearable device to monitor the outdoor time of children in order to prevent myopia progression. Another invention CN107707763A is a myopia prevention and control wearable device and myopia prevention and control system and method, apply a wearable device to monitor the reading illuminance and reading distance in order to prevent the progression of myopia. Another invention CN106289395A is a student myopia prevention and control wearable device, apply a wearable device with ambient light sensor and temperature sensor and laser distance sensor to monitor the student's reading pattern in order to prevent the myopia progression.

The effectiveness of the prior arts are not confirmed, yet the myopia rate all over the world is still high, hence, there is high demand for an effective myopia preventing method or device.

There are studies show that the time of daily outdoor activity is a factor for preventing the myopia progression, hence arose inventions focus on monitor of daily outdoor time and advice the student to adjust their activity for preventing myopia, other inventions focus on light stimulation either with display or with classroom light to stimulate eyes but due to the physiology of eyes, the pupil will constrict in response of high illumination, the stimulate effect is doubtful, besides, high direct illumination will induce macula disease.

Most classroom illumination standard is about 300-500 lux, while the intensity of outdoor illumination is easily arrived 50000 lux, so the intensity of outdoor illumination is higher than that of indoor, but an eye can't stand for long time of illumination more than 2000 lux directly into retina, the retina will be injured. So the pupils and eyelids are acting as a protection device to reduce the illumination directly introduce into retina. The light directly introducing into retina is greatly reduced in outdoor activity due to the active regulation of pupil and eyelids. But outdoor activity is effective in myopia prevention, which is indicated in many studies, so the light pass-through eyelids must play a great role.

The outdoor activity is different in that high illumination light applied directly on the skin in peripheral of eyes which transmit into periorbital tissue and penetrate into the eyeball indirectly, so the retina is not injured by the high illumination, while the transcutaneous light stimulate periorbital skin, subcutaneous tissue, cornea, iris, ciliary body, uveous, lens, sclera, periorbital tissue, choroid, retina pigment epithelium, retina and vitreous indirectly, which induce a subtle biochemical reaction that preventing the progression of myopia.

SUMMARY OF THE INVENTION

The primary object of the present invention is to construct a device which mimic the outdoor illumination that illuminate directly into the periorbital skin, then penetrating into the subcutaneous tissue, and pass through cornea and the iris, ciliary body, lens, transmitting into periorbital tissue, pass through sclera, uvea, choroid, retina pigment epithelium and indirectly by extra-pupillary pathway into retina and vitreous to induce the subtle biochemical reaction which preventing the progression of myopia. Beside that, the light is directed by well-known pupil detection and eyelid detection method by aid of computer and camera to prevent intensive light pass through pupil into eyeball to injury retina. In this design the light intensity can be elevated to as high as 10000 lux to 200000 lux and keep eyeball safely unharmed. And by dynamic avoidance of highly intensive light pass through pupil, the illumination efficiency is greatly increased. The spectrum of light in our invention is preferred to be full spectrum of day light in order to mimic outdoor activity but due to many theories about what spectrum is effective in myopia prevention is not well proved, the spectrum used will not be limit in our unique extra-pupillary lighting method.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 is the system block diagram of the present invention.

FIG. 2 is the schematic diagram of a usage state of the present invention.

FIG. 2A is the schematic diagram of each different illumination area.

FIG. 2B is the fine illumination of each individual light element for cornea region, and its options of arrangement.

FIG. 2C is the options of light source arrangement, and the arrangement of pupil and eyelid detector

FIG. 3 is the schematic diagram of the 1^(st) structural assembly of the present invention.

FIG. 4 is the schematic diagram of the 2^(nd) structural assembly of the present invention.

FIG. 5 is the schematic diagram of the 3^(rd) structural assembly of the present invention.

FIG. 6 is the schematic diagram of the 4^(th) structural assembly of the present invention.

FIG. 7 is the schematic diagram of the 5^(th) structural assembly of the present invention.

FIG. 8 is the schematic diagram of the 6^(th) structural assembly of the present invention.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

Referring to the FIG. 1 , the present invention comprising a light source 10 and a controller 20, wherein the light source 10 comprises various spectra, and the spectra and compositions thereof can be adjusted according to the requirement; the light source 10 can be one type of light source or a composition made up of various light sources, and the illumination level provided by the light source 10 is adjustable and can be adjusted based on different time periods, and the illumination level is greater than 0.5 LUX or program adjusted; the illumination timing of the light source 10 can be continuous, intermittent, a mixture thereof or program adjusted, the illumination period and brightness level can be modified and adjusted on the basis of a clock 30, and the illumination time each day can be adjusted according to a requirement with respect to different myopic person. The preferred average illumination light intensity is 40000-120000 lux to mimic sunny daylight. The preferred light spectrum is full spectrum of daylight but not limited to it.

The light source 10 composed of arrays of fine directed light element which individually direct light to different eyeball front region to cover the most eyeball front area includes eyelids.

The light element of light source 10 illuminate the eyeball from a inclined angle compared to visual axis. The individual light element can be individually controlled by CPU 20 through fine circuit to turn on or off.

The pupil and eyelid detection are well-known knowledge, we use it in our invention. The pupil and eyelid detector 40 composed of an infra-red LED light source 40A and a camera 40B (as shown in FIG. 2C), the pupil and eyelid detector 40 will send photo of pupil position to CPU 20, the CPU 20 will calculate whether the pupil position overlap with the illuminate position of fine individual light element of light source 10. In case that any individual light element illuminate area overlap with pupil region, the CPU 20 will calculate it out and shut that individual light element off, in order to prevent high intensity light to enter into pupil, In this invention, the light illumination intensity can be as high as 10000 lux to 200000 lux, so keep the light illuminate eyeball only by extra-pupillary pathway, or by transcutaneous pathway is important to prevent macular injury.

The controller 20 is a CPU and is electrically connected to the light source 10 and the clock 30, wherein the controller 20 is electrically connected to a battery 21, and the battery 21 supplies power required for the light source 10, the controller 20 and the clock 30. The battery 21 has option of connect to line power supply in case of recharge or high power consumption.

Referring to FIG. 2 , at least one light source 10 of the present invention is projected to and illuminated on skin surrounding eyes, penetrates subcutaneous tissue A, then pass through cornea B, iris C, ciliary body D and lens E, or penetrates a peripheral tissue F of eyeball, sclera G, uvea H, choroid I, retinal pigment epithelium J, and indirectly enters into vitreous L and retina K, so as to prevent myopia from further worsening by inducing microscopic biochemical reactions.

The structure of the present invention has an unlimited appearance design, and can have various types of architectures:

FIG. 2A, designate the different illuminated area near eye, light pass through A1, A2, A3 can be elevated to 10000 lux to 120000 or excess to 200000 lux, as real outdoor sunlight, while individual light element of light source 10 illuminate to B1 to B9 area will be controlled by the pupil and eyelid detector 40, by comparison of overlapping photo calculated by CPU 20, any individual light element of light source 10 illuminating area within B1 to B9 overlapping with pupil zone when the eyelid is open, its individual electric power will be shut off by CPU 20, its electric power will be on again in time of the overlapping is not continued, the calculating frequency is continuous, such as 60 or 120 Hz. The areas of B1-B9 are 5 mm square each, comprises of a total of 15 mm square which cover the average human cornea size of 11-12 mm in diameter.

FIG. 2B, designate the light pathways of the light source 10, the light source 10 comprise of array of individual light element controlled by CPU 20, the individual light element can stake in horizontal version or vertical version. The light source 10 illuminate to A1, A2, A3 will not need to be regulated by pupil and eyelid detector 40, since those area is far away from pupil zone.

FIG. 2C designates the options of light source 10 arrangement, since the LED technology improved in recent years, we can select LED of high power and small, we can select LED of various spectrum as well as full spectrum preferred in our invention.

FIG. 2C(I) the LED element with its necessary optic was arranged in a matrix, the 10B1-10B9 individual fine light element was arranged to shine on the corresponding area of B1-B9 before cornea. The other light source need not so delicate was arranged to shine on area of A1, A2, A3 with its necessary optic adhere with it. 40A is a infra-red light source shine on cornea and 40B is a camera for pupil and eyelid detector. The pupil and eyelid detector is well known technology for decades.

FIG. 2C(II) is an option of 10B1-10B9 be arranged in a horizontal version, pupil and eyelid detector 40A and 40B be arranged in a more separate version and merged with light source element.

FIG. 3 is the 1^(st) embodiment of the present invention, A light source 10 is provided above an existing pair of glasses 100, and the light source 10 can be clamped and fixed on the pair of glasses 100 by using a clamp, while a controller 20 is clamped and fixed next to the light source 10 and electrically connected to the light source 10. Light source 10 comprises fine light element to shine on cornea area was regulated by pupil and eyelid detector which merged in frame of light source 10 to avoid high intensity light shine into pupil.

FIG. 4 is the 2^(nd) embodiment of the present invention, at least one light source 10 is clamped and fixed above, below or laterally to an existing pair of glasses 100, while at least one controller 20 is clamped and fixed next to the light sources 10 and electrically connected to the light sources 10. Light source 10 comprises fine light element to shine on cornea area was regulated by pupil and eyelid detector which merged in frame of light source 10 to avoid high intensity light shine into pupil.

FIG. 5 is the 3^(rd) embodiment of the present invention, A vision corrected person wears an illumination device frame 200, wherein the illumination device frame 200 is provided thereon with at least one light source 10, while a controller 20 is provided next to the light source 10 and electrically connected to the light source 10; illumination provided by the light source 10 can be respectively and individually controlled, or collectively controlled by a unit related to a main program of the illumination device frame 200. Light source 10 comprises fine light element to shine on cornea area was regulated by pupil and eyelid detector which merged in frame of light source 10 to avoid high intensity light shine into pupil.

FIG. 6 is the 4^(th) embodiment of the present invention, A vision corrected person wears a pair of virtual reality (VR) or augmented reality (AR) glasses 300, wherein the pair of VR or AR glasses 300 or a frame similar thereto such as other head mount display is provided thereon with at a light source 10, while a controller 20 is provided next to the light source 10 and electrically connected to the light source 10; illumination provided by the light source 10 can be respectively and individually controlled, or collectively controlled by a unit related to a main program of the pair of VR or AR glasses 300 or the frame similar thereto. Light source 10 comprises fine light element to shine on cornea area was regulated by pupil and eyelid detector which merged in frame of light source 10 to avoid high intensity light shine into pupil.

FIG. 7 is the 5^(th) embodiment of the present invention, It comprising a customized glasses frame 400, at least one light source 10 is directly provided on the glasses frame 400 so as to provide illumination, while a controller 20 is provided next to the light source 10 and electrically connected to the light source 10. Light source 10 comprises fine light element to shine on cornea area was regulated by pupil and eyelid detector which merged in frame of light source 10 to avoid high intensity light shine into pupil.

FIG. 8 is the 6^(th) embodiment of the present invention, It comprising a customized headgear 500, and at least one light source 10 is provided on an edge 501 of the headgear 500, while a controller 20 is provided in an adequate position on the headgear 500, and the controller 20 is electrically connected to the light source 10. Light source 10 comprises fine light element to shine on cornea area was regulated by pupil and eyelid detector which merged in frame of light source 10 to avoid high intensity light shine into pupil.

In summary, the present invention is to construct a device which mimic the outdoor high illumination in real life, the high intensity light of outdoor activity can prevent myopia progression, protect human heart, prevent DM, healthy for human, but the averaged light intensity of sunny daylight is 40000 to 120000 lux and up excess to 200000, which definitely cannot be allowed to pass directly through pupil into eyeball, the majority of daylight shine mostly on periorbital skin and enter eyeball through an extra-pupillary pathway. Our invention is to fulfill the high intensity light illumination of outdoor activity and improve the efficiency by wearable, direct extra-pupillary illumination, duty time control, intensity control, which will be helpful for people lack outdoor time.

It is of course to be understood that the embodiments described herein are merely illustrative of the principles of the invention and that a wide variety of modifications thereto may be effected by persons skilled in the art without departing from the spirit and scope of the invention as set forth in the following claims.

REFERENCE

-   1. What Do Animal Studies Tell Us about the Mechanism of     Myopia-Protection by Light? Norton T T. Optom Vis Sci. 2016     September; 93(9):1049-51. doi: 10.1097/OPX.0000000000000917. -   2. Animal Studies and the Mechanism of Myopia-Protection by Light?     Ashby R. Optom Vis Sci. 2016 September; 93(9):1052-4. doi:     10.1097/OPX.0000000000000978. -   3. The effect of bright light on lens compensation in chicks. Ashby     R S, Schaeffel F. Invest Ophthalmol Vis Sci. 2010 October;     51(10):5247-53. doi: 10.1167/iovs.09-4689. Epub 2010 May 5. -   4. Correlation between light levels and the development of     deprivation myopia. Karouta C, Ashby R S. Invest Ophthalmol Vis Sci.     2014 Dec. 9; 56(1):299-309. doi: 10.1167/iovs.14-15499. -   5. The effect of ambient illuminance on the development of     deprivation myopia in chicks. Ashby R, Ohlendorf A, Schaeffel F.     Invest Ophthalmol Vis Sci. 2009 November; 50(11):5348-54. doi:     10.1167/iovs.09-3419. Epub 2009 Jun. 10. -   6. Light levels, refractive development, and myopia—a speculative     review. Norton T T, Siegwart J T Jr. Exp Eye Res. 2013 September;     114:48-57. doi: 10.1016/j.exer.2013.05.004. Epub 2013 May 13. -   7. Protective effects of high ambient lighting on the development of     form-deprivation myopia in rhesus monkeys. Smith E L 3rd, Hung L F,     Huang J. Invest Ophthalmol Vis Sci. 2012 Jan. 25; 53(1):421-8. doi:     10.1167/iovs.11-8652. -   8. Influence of periodic vs continuous daily bright light exposure     on development of experimental myopia in the chick. Backhouse S,     Collins A V, Phillips J R. Ophthalmic Physiol Opt. 2013 September;     33(5):563-72. doi: 10.1111/opo.12069. Epub 2013 May 13. -   9. Bright Light Suppresses Form-Deprivation Myopia Development With     Activation of Dopamine D1 Receptor Signaling in the ON Pathway in     Retina. Chen S, Zhi Z, Ruan Q, Liu Q, Li F, Wan F, Reinach P S, Chen     J, Qu J, Zhou X. Invest Ophthalmol Vis Sci. 2017 Apr. 1;     58(4):2306-2316. doi: 10.1167/iovs.16-20402. -   10. Intense Light-Mediated Circadian Cardioprotection via     Transcriptional Reprogramming of the Endothelium Oyama et al.,     (2019, Cell Reports 28, 1471-1484) 

What is claimed is:
 1. A myopia-preventing high intensity illumination apparatus for illuminating eyeballs and surrounding tissues via light that penetrating periorbital skin, subcutaneous tissue, then pass through cornea, iris, uvea, sclera and choroid, comprising a light source and a controller electrically connects to the light source, wherein the light source is projects to and illuminates on skin surrounding eyes, penetrates and enters subcutaneous tissue, iris, ciliary body and lens, as well as penetrates peripheral tissues of eyeballs, sclera, uvea, choroid and retinal pigment epithelium, and indirectly enters into vitreous and retina, so as to prevent myopia from further worsening by inducing microscopic biochemical reactions.
 2. The myopia-preventing high intensity illumination apparatus for illuminating eyeballs and surrounding tissues via light that penetrating periorbital skin, subcutaneous tissue, then pass through cornea, iris, uvea, sclera and choroid according to claim 1, wherein the light source comprises various spectra, wherein the spectra and compositions thereof can be adjusted according to a requirement, the light source can be one type of light source or a composition of various light sources, the illumination level provided by the light source is adjustable, and being adjusted to greater than 0.5 LUX or program adjusted based on different time periods; the illumination timing of the illumination provided by the light source being continuous, intermittent, a mixture thereof or program adjusted, and the illumination period and the brightness level of the illumination provided by the light source can be modified and adjusted on the basis of a clock.
 3. The myopia-preventing high intensity illumination apparatus for illuminating eyeballs and surrounding tissues via light that penetrating periorbital skin, subcutaneous tissue, then pass through cornea, iris, uvea, sclera and choroid according to claim 1, wherein the light is fine directed by pupil and eyelid detector and controlled by CPU to avoid high intensity light to pass through pupil aperture.
 4. The myopia-preventing high intensity illumination apparatus for illuminating eyeballs and surrounding tissues via light that penetrating periorbital skin, subcutaneous tissue, then pass through cornea, iris, uvea, sclera and choroid according to claim 1, the light illuminating eyeballs and surrounding tissue through an extra-pupillary pathway.
 5. The myopia-preventing high intensity illumination apparatus for illuminating eyeballs and surrounding tissues via light that penetrating periorbital skin, subcutaneous tissue, then pass through cornea, iris, uvea, sclera and choroid according to claim 1, the light intensity of light source is preferred but not limited to 1000 lux to 120000 lux.
 6. The myopia-preventing high intensity illumination apparatus for illuminating eyeballs and surrounding tissues via light that penetrating periorbital skin, subcutaneous tissue, then pass through cornea, iris, uvea, sclera and choroid according to claim 1, wherein the light source is provided above, below or laterally to a pair of glasses.
 7. The myopia-preventing high intensity illumination apparatus for illuminating eyeballs and surrounding tissues via light that penetrating periorbital skin, subcutaneous tissue, then pass through cornea, iris, uvea, sclera and choroid according to claim 1, wherein the light source and necessary components being provided on a pair of VR or AR glasses or a frame similar thereto, wherein illumination provided by the light source being respectively and individually controlled, or collectively controlled by a main program of the pair of VR or AR glasses or the frame similar thereto.
 8. The myopia-preventing high intensity illumination apparatus for illuminating eyeballs and surrounding tissues via light that penetrating periorbital skin, subcutaneous tissue, then pass through cornea, iris, uvea, sclera and choroid according to claim 1, wherein the light source and necessary components being constructed to merge with a glasses frame.
 9. The myopia-preventing high intensity illumination apparatus for illuminating eyeballs and surrounding tissues via light that penetrating periorbital skin, subcutaneous tissue, then pass through cornea, iris, uvea, sclera and choroid according to claim 1, wherein the light source and necessary components being constructed to merge with a headgear. 